Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1

Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1

Individuals with neurofibromatosis type 1 (NF1) frequently exhibit cognitive and motor impairments and characteristics of autism. The cerebellum plays a critical role in motor control, cognition, and social interaction, suggesting that cerebellar defects likely contribute to NF1-associated neurodeve...

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Bibliographic Details
Main Authors: Edward Kim, Yuan Wang, Sun-Jung Kim, Miriam Bornhorst, Emmanuelle S Jecrois, Todd E Anthony, Chenran Wang, Yi E Li, Jun-Lin Guan, Geoffrey G Murphy, Yuan Zhu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-12-01
Series:eLife
Subjects:
neurofibromatosis type 1
cerebellum
bergmann glial cell
granule cell
unipolar brush cell
tumor suppressor gene
Online Access:https://elifesciences.org/articles/05151

Internet

https://elifesciences.org/articles/05151

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