The Use of Beta Blockers in Takotsubo Syndrome as Compared to Acute Coronary Syndrome

• Main Authors: Marvin Kummer, Ibrahim El-Battrawy, Thorsten Gietzen, Uzair Ansari, Michael Behnes, Siegfried Lang, Xiaobo Zhou, Martin Borggrefe, Ibrahim Akin
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-05-01
• Series: Frontiers in Pharmacology
• Subjects: Takotsubo syndrome (TTS); acute coronary syndrome; beta-blockers; long-term mortality; ace-inhibitors
• Online Access: https://www.frontiersin.org/article/10.3389/fphar.2020.00681/full

BackgroundTakotsubo syndrome (TTS) and acute coronary syndrome (ACS) patients have a similar mortality rate. In this study, we sought to determine the short- and long-term outcome of TTS patients as compared to ACS patients both treated with beta-blockers.ObjectivesIn the present study we described the data of 5 years of follow up of 103 TTS and 422 ACS patients both treated with beta-blockers.MethodsData from TTS patients were included retrospectively and prospectively, ACS patients were included retrospectively. All retrospectively included patients have been followed up for 5 years. The end point in this study was the occurrence of death.ResultsTTS affected significantly more women (87.4%) than ACS (34.6%) (p < 0.01). TTS patients suffered significantly more often from thromboembolic events (14.6% versus 2.1%; p < 0.01) and cardiogenic shock (11.9% versus 3.6%; p < 0.01) than the ACS group. TTS patients had a significantly higher long-term mortality (within 5 years) as compared to ACS patients (17.5% versus 3.6%) (p < 0.01). Patients of the TTS group compared to the ACS group did not benefit from combination of beta-blockers and ACE-inhibitors in terms of long-term mortality (p < 0.01). As we compare TTS patients who were treated with beta-blockers and ACE-inhibitors versus single use of beta-blockers there was no difference in long-term mortality (p = 0.918).ConclusionTTS patients had a significantly higher long-term mortality (within 5 years) than patients with an ACS.