EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION

EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION

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<strong>Abstract. </strong>Intraperitoneal injection of rIL-1β (1 mkg/kg once a day within 5 days) during proceeding fractional irradiations (0,5 Gy once in day, the beginning of therapy after the total doze 20 Gy) prevents the further decrease in quantity of leukocytes in peripheral blo...

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Main Authors: A. N. Grebenyuk, V. V. Konev, A. A. Timoshevskiy
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
fractional irradiations
rIL-1β
leukocytes
neutrophils
lymphocytes
Online Access:http://mimmun.ru/index.php/mimmun/article/view/652
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spelling doaj-6982179233bd472f992925ca75e7288d2020-11-24T21:11:23ZrusSPb RAACIMedicinskaâ Immunologiâ1563-06252313-741X2014-07-0175–660561010.15789/1563-0625-2005-5–6-605-610649EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATIONA. N. Grebenyuk0V. V. Konev1A. A. Timoshevskiy2Военно медицинская академия С.М. Кирова, г. Санкт-ПетербургВоенно медицинская академия С.М. Кирова, г. Санкт-ПетербургВоенно медицинская академия С.М. Кирова, г. Санкт-Петербург<strong>Abstract. </strong>Intraperitoneal injection of rIL-1β (1 mkg/kg once a day within 5 days) during proceeding fractional irradiations (0,5 Gy once in day, the beginning of therapy after the total doze 20 Gy) prevents the further decrease in quantity of leukocytes in peripheral blood and oppression of alkaline phosphatase activity in neutrophils of irradiated rats, and also accelerates their restoration after cessation of radiatijn exposure. Restoration of the general number of leukocytes, absolute quantity of neutrophils and lymphocytes, normalization of the alkaline phosphatase activity in neutrophils of rats after the end of fractional irradiations in a total doze 25 Gy at course administration of rIL-1β occur in earlier terms, than in the animals of the control group.http://mimmun.ru/index.php/mimmun/article/view/652fractional irradiationsrIL-1βleukocytesneutrophilslymphocytes
collection DOAJ
language Russian
format Article
sources DOAJ
author A. N. Grebenyuk
V. V. Konev
A. A. Timoshevskiy
spellingShingle A. N. Grebenyuk
V. V. Konev
A. A. Timoshevskiy
EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
Medicinskaâ Immunologiâ
fractional irradiations
rIL-1β
leukocytes
neutrophils
lymphocytes
author_facet A. N. Grebenyuk
V. V. Konev
A. A. Timoshevskiy
author_sort A. N. Grebenyuk
title EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
title_short EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
title_full EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
title_fullStr EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
title_full_unstemmed EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION
title_sort experimental proof of the efficacy of recombinant il-1β in fractional irradiation
publisher SPb RAACI
series Medicinskaâ Immunologiâ
issn 1563-0625
2313-741X
publishDate 2014-07-01
description <strong>Abstract. </strong>Intraperitoneal injection of rIL-1β (1 mkg/kg once a day within 5 days) during proceeding fractional irradiations (0,5 Gy once in day, the beginning of therapy after the total doze 20 Gy) prevents the further decrease in quantity of leukocytes in peripheral blood and oppression of alkaline phosphatase activity in neutrophils of irradiated rats, and also accelerates their restoration after cessation of radiatijn exposure. Restoration of the general number of leukocytes, absolute quantity of neutrophils and lymphocytes, normalization of the alkaline phosphatase activity in neutrophils of rats after the end of fractional irradiations in a total doze 25 Gy at course administration of rIL-1β occur in earlier terms, than in the animals of the control group.
topic fractional irradiations
rIL-1β
leukocytes
neutrophils
lymphocytes
url http://mimmun.ru/index.php/mimmun/article/view/652
work_keys_str_mv AT angrebenyuk experimentalproofoftheefficacyofrecombinantil1binfractionalirradiation
AT vvkonev experimentalproofoftheefficacyofrecombinantil1binfractionalirradiation
AT aatimoshevskiy experimentalproofoftheefficacyofrecombinantil1binfractionalirradiation
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