EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION

EXPERIMENTAL PROOF OF THE EFFICACY OF RECOMBINANT IL-1β IN FRACTIONAL IRRADIATION

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<strong>Abstract. </strong>Intraperitoneal injection of rIL-1β (1 mkg/kg once a day within 5 days) during proceeding fractional irradiations (0,5 Gy once in day, the beginning of therapy after the total doze 20 Gy) prevents the further decrease in quantity of leukocytes in peripheral blo...

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Bibliographic Details
Main Authors: A. N. Grebenyuk, V. V. Konev, A. A. Timoshevskiy
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
fractional irradiations
rIL-1β
leukocytes
neutrophils
lymphocytes
Online Access:http://mimmun.ru/index.php/mimmun/article/view/652
Description
Summary:<strong>Abstract. </strong>Intraperitoneal injection of rIL-1β (1 mkg/kg once a day within 5 days) during proceeding fractional irradiations (0,5 Gy once in day, the beginning of therapy after the total doze 20 Gy) prevents the further decrease in quantity of leukocytes in peripheral blood and oppression of alkaline phosphatase activity in neutrophils of irradiated rats, and also accelerates their restoration after cessation of radiatijn exposure. Restoration of the general number of leukocytes, absolute quantity of neutrophils and lymphocytes, normalization of the alkaline phosphatase activity in neutrophils of rats after the end of fractional irradiations in a total doze 25 Gy at course administration of rIL-1β occur in earlier terms, than in the animals of the control group.
ISSN:1563-0625
2313-741X

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