Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening

High-throughput cell-based screening of compound libraries is utilised in drug development; however, a lack of compatible methods limits direct synthesis and testing. Here, the authors present a diverse chip based synthesis system which can be combined with cell screening and demonstrate the applica...

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Main Authors:	Maximilian Benz, Mijanur R. Molla, Alexander Böser, Alisa Rosenfeld, Pavel A. Levkin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10685-0

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spelling	doaj-6979685daa8a4f89bb0739d8f7eb3a4f2021-05-11T11:58:36ZengNature Publishing GroupNature Communications2041-17232019-06-0110111010.1038/s41467-019-10685-0Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screeningMaximilian Benz0Mijanur R. Molla1Alexander Böser2Alisa Rosenfeld3Pavel A. Levkin4Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics (ITG)Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics (ITG)Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics (ITG)Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics (ITG)Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics (ITG)High-throughput cell-based screening of compound libraries is utilised in drug development; however, a lack of compatible methods limits direct synthesis and testing. Here, the authors present a diverse chip based synthesis system which can be combined with cell screening and demonstrate the application.https://doi.org/10.1038/s41467-019-10685-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maximilian Benz Mijanur R. Molla Alexander Böser Alisa Rosenfeld Pavel A. Levkin
spellingShingle	Maximilian Benz Mijanur R. Molla Alexander Böser Alisa Rosenfeld Pavel A. Levkin Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening Nature Communications
author_facet	Maximilian Benz Mijanur R. Molla Alexander Böser Alisa Rosenfeld Pavel A. Levkin
author_sort	Maximilian Benz
title	Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
title_short	Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
title_full	Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
title_fullStr	Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
title_full_unstemmed	Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
title_sort	marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-06-01
description	High-throughput cell-based screening of compound libraries is utilised in drug development; however, a lack of compatible methods limits direct synthesis and testing. Here, the authors present a diverse chip based synthesis system which can be combined with cell screening and demonstrate the application.
url	https://doi.org/10.1038/s41467-019-10685-0
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Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening

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