Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection

Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection

Certain cytokines modulate the expression of insulin-like growth factor- (IGF-) I. Since IL-4 and IGF-I promote growth of the protozoan Leishmania major, we here addressed their interaction in downregulating the expression of Igf-I mRNA using small interfering RNA (siRNA) in Leishmania major-infecte...

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Bibliographic Details
Main Authors:	Luiza C. Reis, Eduardo Milton Ramos-Sanchez, Fabricio Petitto-Assis, Audun H. Nerland, Maria Hernandez-Valladares, Frode Selheim, Lucile Maria Floeter-Winter, Hiro Goto
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2018/9787128

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