Automated Live-Cell Imaging of Synapses in Rat and Human Neuronal Cultures

Automated Live-Cell Imaging of Synapses in Rat and Human Neuronal Cultures

Synapse loss and dendritic damage correlate with cognitive decline in many neurodegenerative diseases, underlie neurodevelopmental disorders, and are associated with environmental and drug-induced CNS toxicities. However, screening assays designed to measure loss of synaptic connections between live...

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Bibliographic Details
Main Authors: Matthew V. Green, Thomas Pengo, Jonathan D. Raybuck, Tahmina Naqvi, Hannah M. McMullan, Jon E. Hawkinson, Ezequiel Marron Fernandez de Velasco, Brian S. Muntean, Kirill A. Martemyanov, Rachel Satterfield, Samuel M. Young, Stanley A. Thayer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
synapse loss
synaptogenesis
automated microscopy
image processing
viral transduction
human iPSC
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00467/full

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