Copper induces hepatocyte autophagy via the mammalian targets of the rapamycin signaling pathway in mice

Copper induces hepatocyte autophagy via the mammalian targets of the rapamycin signaling pathway in mice

Although copper is among the indispensable trace elements in animal physiological processes, it exerts toxicity upon over-exposure. The present study aimed to investigate hepatocyte autophagy induced by CuSO4 and its potential mechanism. A total of 240 ICR mice (four-week-old, 120 males and 120 fema...

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Bibliographic Details
Main Authors: Huan Liu, Huidan Deng, Hengmin Cui, Zhijie Jian, Hongrui Guo, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
CuSO4
Autophagy
MTOR signaling pathway
Liver
Mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651320314937

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http://www.sciencedirect.com/science/article/pii/S0147651320314937

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