The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae.

The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae.

DFNA5 was first identified as a gene responsible for autosomal dominant deafness. Different mutations were found, but they all resulted in exon 8 skipping during splicing and premature termination of the protein. Later, it became clear that the protein also has a tumor suppression function and that...

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Bibliographic Details
Main Authors: Sofie eVan Rossom, Ken eOp de Beeck, Vanessa eFranssens, Erwin eSwinnen, Anne eSchepers, Ruben eGhillebert, Marina eCaldara, Guy eVan Camp, Joris eWinderickx
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
Cell Death
Saccharomyces cerevisiae
yeast
tumor suppressor
DFNA5
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00077/full

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