ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS

ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS

Abstract. The review article presents data concerning pathogenetic mechanisms of acute pancreatitis development and poly-organ insufficiency. It was shown IL-1 is among important factors that may determine a severity degree of pancreatitis. Production of this cytokine provides clinical features of a...

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Main Authors: A. N. Plekhanov, D. I. Reshetnikov, A. I. Tovarshinov
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
acute pancreatitis
pathogenesis
il-1
peroxidation products
Online Access:https://www.mimmun.ru/mimmun/article/view/274
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spelling doaj-695816b7a97d4291b41df52cdba2fcf22021-07-29T09:02:23ZrusSPb RAACIMedicinskaâ Immunologiâ1563-06252313-741X2014-07-01112-314114610.15789/1563-0625-2009-2-3-141-146271ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITISA. N. Plekhanov0D. I. Reshetnikov1A. I. Tovarshinov2Бурятский филиал научного центра реконструктивной и восстановительной хирургии ВСНЦ СО РАМН, г. Улан-УдэБурятский филиал научного центра реконструктивной и восстановительной хирургии ВСНЦ СО РАМН, г. Улан-УдэБурятский филиал научного центра реконструктивной и восстановительной хирургии ВСНЦ СО РАМН, г. Улан-УдэAbstract. The review article presents data concerning pathogenetic mechanisms of acute pancreatitis development and poly-organ insufficiency. It was shown IL-1 is among important factors that may determine a severity degree of pancreatitis. Production of this cytokine provides clinical features of acute pancreatitis, as well as direct cytotoxic effect upon tumor cells. The article also deals with intensified lipid superoxide generation caused by IL-1. Upon development of inflammatory events, interactions between free radicals and membrane lipids provide synthesis of superoxide compounds that display distinct chemotactic activity towards phagocytes and other immunocompetent cells.https://www.mimmun.ru/mimmun/article/view/274acute pancreatitispathogenesisil-1peroxidation products
collection DOAJ
language Russian
format Article
sources DOAJ
author A. N. Plekhanov
D. I. Reshetnikov
A. I. Tovarshinov
spellingShingle A. N. Plekhanov
D. I. Reshetnikov
A. I. Tovarshinov
ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
Medicinskaâ Immunologiâ
acute pancreatitis
pathogenesis
il-1
peroxidation products
author_facet A. N. Plekhanov
D. I. Reshetnikov
A. I. Tovarshinov
author_sort A. N. Plekhanov
title ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
title_short ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
title_full ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
title_fullStr ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
title_full_unstemmed ROLE OF IL-1 AND LIPID PEROXIDATION PRODUCTS IN PATHOGENESIS OF ACUTE PANCREATITIS
title_sort role of il-1 and lipid peroxidation products in pathogenesis of acute pancreatitis
publisher SPb RAACI
series Medicinskaâ Immunologiâ
issn 1563-0625
2313-741X
publishDate 2014-07-01
description Abstract. The review article presents data concerning pathogenetic mechanisms of acute pancreatitis development and poly-organ insufficiency. It was shown IL-1 is among important factors that may determine a severity degree of pancreatitis. Production of this cytokine provides clinical features of acute pancreatitis, as well as direct cytotoxic effect upon tumor cells. The article also deals with intensified lipid superoxide generation caused by IL-1. Upon development of inflammatory events, interactions between free radicals and membrane lipids provide synthesis of superoxide compounds that display distinct chemotactic activity towards phagocytes and other immunocompetent cells.
topic acute pancreatitis
pathogenesis
il-1
peroxidation products
url https://www.mimmun.ru/mimmun/article/view/274
work_keys_str_mv AT anplekhanov roleofil1andlipidperoxidationproductsinpathogenesisofacutepancreatitis
AT direshetnikov roleofil1andlipidperoxidationproductsinpathogenesisofacutepancreatitis
AT aitovarshinov roleofil1andlipidperoxidationproductsinpathogenesisofacutepancreatitis
_version_ 1721250055845838848

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