Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts.

Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts.

Evidence from both GWAS and clinical observation has suggested that certain psychiatric, metabolic, and autoimmune diseases are heterogeneous, comprising multiple subtypes with distinct genomic etiologies and Polygenic Risk Scores (PRS). However, the presence of subtypes within many phenotypes is fr...

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Bibliographic Details
Main Authors: Jie Yuan, Henry Xing, Alexandre Louis Lamy, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Todd Lencz, Itsik Pe'er
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009015

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