miR-221-3p Drives the Shift of M2-Macrophages to a Pro-Inflammatory Function by Suppressing JAK3/STAT3 Activation

miR-221-3p Drives the Shift of M2-Macrophages to a Pro-Inflammatory Function by Suppressing JAK3/STAT3 Activation

Objectives: Macrophages are conventionally classified as pro-inflammatory (M1) and anti-inflammatory (M2) functional types. There is evidence for a predominance of macrophages with an inflammatory phenotype (M1) in the rheumatoid arthritis (RA) synovium. MicroRNAs (miRs) play a pivotal role in regul...

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Bibliographic Details
Main Authors: Lilian Quero, André N. Tiaden, Edveena Hanser, Julien Roux, Artur Laski, Jonathan Hall, Diego Kyburz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
innate immunity
macrophages (M1/M2)
microRNAs
TLRs
RNA-seq
JAK3/STAT3
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03087/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03087/full

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