How to Control HTLV-1-Associated Diseases: Preventing de Novo Cellular Infection Using Antiviral Therapy

How to Control HTLV-1-Associated Diseases: Preventing de Novo Cellular Infection Using Antiviral Therapy

Five to ten million individuals are infected by Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 is transmitted through prolonged breast-feeding, by sexual contacts and by transmission of infected T lymphocytes through blood transfusion. One to ten percent of infected carriers will develop a seve...

Full description

Bibliographic Details
Main Authors:	Amandine Pasquier, Sandrine Alais, Loic Roux, Maria-Isabel Thoulouze, Karine Alvarez, Chloé Journo, Hélène Dutartre, Renaud Mahieux
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-03-01
Series:	Frontiers in Microbiology
Subjects:	HTLV-1 antiviral therapy proviral load acyclic nucleoside phosphonates and thiophosphonates AZT prodrugs
Online Access:	http://journal.frontiersin.org/article/10.3389/fmicb.2018.00278/full

Similar Items

HTLV-1 and Innate Immunity
by: Chloé Journo, et al.
Published: (2011-08-01)

Dendritic cell maturation, but not type I interferon exposure, restricts infection by HTLV-1, and viral transmission to T-cells.
by: Gergès Rizkallah, et al.
Published: (2017-04-01)

Correction: Dendritic cell maturation, but not type I interferon exposure, restricts infection by HTLV-1, and viral transmission to T-cells.
by: Gergès Rizkallah, et al.
Published: (2017-07-01)

HTLV-1 infection of myeloid cells: from transmission to immune alterations
by: Brenda Rocamonde, et al.
Published: (2019-12-01)

HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment
by: Nicolas Futsch, et al.
Published: (2017-12-01)

Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents
by: Pramod K. Sahu, et al.
Published: (2017-07-01)

STLV-1 as a model for studying HTLV-1 infection
by: Brice Jégado, et al.
Published: (2019-12-01)

Adenine: an important drug scaffold for the design of antiviral agents
by: Changyuan Wang, et al.
Published: (2015-09-01)

Cytokine Networks Dysregulation during HTLV-1 Infection and Associated Diseases
by: Nicolas Futsch, et al.
Published: (2018-12-01)

Carga proviral do HTLV-1 e HTLV-2: um método simples através da PCR quantitativa em tempo real HTLV-1 and HTLV-2 proviral load: a simple method using quantitative real-time PCR
by: Bruna Pedroso Tamegão-Lopes, et al.
Published: (2006-12-01)

Microbial Biofilms: Human T-cell Leukemia Virus Type 1 First in Line for Viral Biofilm but Far Behind Bacterial Biofilms
by: Yousef Maali, et al.
Published: (2020-09-01)

Tenothiovir et Adethiovir : Nouveaux analogues phosphonates acycliques pour cibler les VIH-1 résistants
by: Roux, Loic
Published: (2012)

HTLV-3/STLV-3 and HTLV-4 Viruses: Discovery, Epidemiology, Serology and Molecular Aspects
by: Antoine Gessain, et al.
Published: (2011-07-01)

Comparison of HTLV-I Proviral Load in Adult T Cell Leukemia/Lymphoma (ATL), HTLV-I-Associated Myelopathy (HAM-TSP) and Healthy Carriers
by: Mohammad Mehdi Akbarin, et al.
Published: (2013-03-01)

Contribution des catalyseurs contenant un carbène N-hétérocyclique pour la chimie des nucléosides
by: Broggi, Julie
Published: (2009)

Selected Thoughts on Hydrophobicity in Drug Design
by: Lillian L. Lou, et al.
Published: (2021-02-01)

An improved synthesis of adefovir and related analogues
by: David J. Jones, et al.
Published: (2019-03-01)

Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study
by: Sônia Sampaio Lôpo, et al.
Published: (2012-06-01)

Interaction of perforin and granzyme B and HTLV-1 viral factors is associated with ATL development
by: Mohammad Mehdi Akbarin, et al.
Published: (2020-08-01)

STLV-1 co-infection is correlated with an increased SFV proviral load in the peripheral blood of SFV/STLV-1 naturally infected non-human primates.
by: Sandrine Alais, et al.
Published: (2018-10-01)

Synthesis and Early Development of Hexadecyloxypropyl-cidofovir: An Oral Antipoxvirus Nucleoside Phosphonate
by: Karl Y. Hostetler
Published: (2010-09-01)

Evolution of HTLV-1 proviral load in patients from Salvador, Brazil
by: Viviana Nilla Olavarria, et al.

High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
by: J. Primo, et al.
Published: (2009-08-01)

Human T-lymphotropic Virus Type I (HTLV-I) Proviral Load and Clinical Features in Iranian HAM/TSP Patients
by: Rosita Vakili, et al.
Published: (2013-03-01)

Association between HLA Class I Alleles and Proviral Load in HTLV-I Associated Myelopathy/Tropical Spastic Paraperesis (HAM/TSP) Patients in Iranian Population
by: Mahdi Taghaddosi, et al.
Published: (2013-03-01)

Synthesis and Antiviral Evaluation of 3′-Fluoro-5′-norcarbocyclic Nucleoside Phosphonates Bearing Uracil and Cytosine as Potential Antiviral Agents
by: Pierre-Yves Geant, et al.
Published: (2020-08-01)

Perfil de ativação dos linfócitos T de pacientes com mielopatia associada ao vírus linfotrópico das células T humanas do tipo 1 (HTLV-1) / paraparesia tropical espástica (HAM/TSP) possível, provável e definido
by: Coutinho Junior, Raimundo
Published: (2014)

Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil
by: Doris Schor, et al.
Published: (2018-11-01)

Sensing of cell-associated HTLV by plasmacytoid dendritic cells is regulated by dense β-galactoside glycosylation.
by: Sonia Assil, et al.
Published: (2019-02-01)

Análise do níveis de carga proviral e da expressão dos genes virais tax e HBZ na leucemia/linfoma de células T do adulto (ATL)
by: Núñez, Isabela Archanjo
Published: (2013)

Historical Perspectives in the Development of Antiviral Agents Against Poxviruses
by: Erik De Clercq
Published: (2010-06-01)

TRAF3 Is Required for NF-κB Pathway Activation Mediated by HTLV Tax Proteins
by: Stefania Fochi, et al.
Published: (2019-06-01)

Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load
by: Sanabani Sabri Saeed, et al.
Published: (2012-12-01)

Assessment of HTLV-I proviral load, HIV viral load and CD4 T cell count in infected subjects; with an emphasis on viral replication in co-infection
by: Hossein Rahimi, et al.
Published: (2014-01-01)

Análise da integração viral e clonalidade de linfócitos T na dermatite infecciosa associada ao HTLV-1.
by: Argôlo, Juliana Moreira
Published: (2015)

Synthèse métallo-catalysée de phosphonates trans-but-2'-ényl de nucléosides sous forme prodrogue
by: Bessières, Maxime
Published: (2016)

SÍNTESE E ATIVIDADES ANTIOXIDANTE E ANTITUMORAL DE 5´-ARILSELENO AZIDOTIMIDINA
by: Souza, Diego de
Published: (2013)

Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
by: Gennaro Piccialli, et al.
Published: (2013-08-01)

The Effect of Number and Position of P=O/P=S Bridging Units on Cavitand Selectivity toward Methyl Ammonium Salts
by: Daniela Menozzi, et al.
Published: (2015-03-01)

AZT as a telomerase inhibitor
by: Daniel E Gomez, et al.
Published: (2012-09-01)