Effect of glutamine enteral nutrition + low molecular weight heparin on systemic inflammatory response in patients with severe pneumonia

• Main Authors: Yan-Ping Ye, Lei-Ying Song
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-08-01
• Series: Journal of Hainan Medical University
• Subjects: Severe pneumonia; Glutamine enteral nutrition; Low molecular weight heparin; Systemic inflammatory response
• Online Access: http://www.hnykdxxb.com/PDF/201815/07.pdf

Objective: To investigate the effect of glutamine enteral nutrition + low molecular weight heparin on systemic inflammatory response in patients with severe pneumonia. Methods: A total of 52 patients with severe pneumonia who were hospitalized in this hospital between January 2017 and October 2017 were divided into glutamine group (n=26) and control group (n=26) by random number table method. Control group received conventional enteral nutrition + low molecular weight heparin treatment, glutamine group were treated with glutamine nutrient solution on the basis of the therapy for control group, and both therapies lasted for 7 d. The differences in serum levels of inflammatory factors, oxidative stress indexes and myocardial injury indexes were compared between the two groups before and after treatment. Results: Before treatment, serum levels of inflammatory factors, oxidative stress indexes and myocardial injury indexes were not significantly different between the two groups. After 7 d of treatment, serum inflammatory factors IL-10 and IL-18 levels of glutamine group were higher than those of control group whereas IL-17, sTREM-1 and PCT levels were lower than those of control group; serum oxidative stress indexes MDA and LHP levels were lower than those of control group whereas GSH-Px and CAT levels were higher than those of control group; serum myocardial injury indexes α-HBDH, cTnⅠ, NT-ProBNP and LDH levels were lower than those of control group. Conclusion: glutamine enteral nutrition + low molecular weight heparin can effectively relieve systemic inflammatory response and oxidative stress response, and reduce the myocardial injury in patients with severe pneumonia.