Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8

Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8

Abstract Background Apoe-deficient (Apoe −/−) mice develop progressive atherosclerotic lesions with age but no severe renal pathology in the absence of additional challenges. We recently described accelerated atherosclerosis as well as marked renal injury in Apoe −/− mice deficient in the mesenchyma...

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Bibliographic Details
Main Authors: Ines Marek, Maurizio Canu, Nada Cordasic, Manfred Rauh, Gudrun Volkert, Fabian B. Fahlbusch, Wolfgang Rascher, Karl F. Hilgers, Andrea Hartner, Carlos Menendez-Castro
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Biology of Sex Differences
Subjects:
α8 integrin
Itga8
Atherosclerotic lesions
Renal lesions
Knockout mice
Sex differences
Online Access:http://link.springer.com/article/10.1186/s13293-017-0141-y

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