Association of adipokines and adhesion molecules with indicators of obesity in women undergoing mammography screening

• Main Authors: Isoppo de Souza Caroline, Rosa Daniela Dornelles, Ettrich Betina, Cibeira Gabriela Hermann, Giacomazzi Juliana, Tusset Paloma, Ashton-Prolla Patrícia, Medeiros Lidia Rosi, Caleffi Maira, Neto Eurico Camargo, Moriguchi Emilio Hideyuki, Graudenz Marcia Silveira
• Format: Article
• Language: English
• Published: BMC 2012-10-01
• Series: Nutrition & Metabolism
• Subjects: Obesity; Adiponectin; Plasminogen Activator Inhibitor type-1; Vascular Cell Adhesion Molecule-1; Intercellular Adhesion Molecule-1
• Online Access: http://www.nutritionandmetabolism.com/content/9/1/97

<p>Abstract</p> <p>Background</p> <p>The soluble cell adhesion molecules and adipokines are elevated in patients with obesity, hypertension, type 2 diabetes mellitus, breast cancer and atherosclerosis<b>.</b></p> <p>Objective</p> <p>To investigate the relationship between anthropometric profile, dietary intake, lipid profile and fasting glycemia with serum levels of adipokines (adiponectin and PAI-1) and adhesion molecules (ICAM-1 and VCAM-1) in women without breast cancer undergoing routine mammographic screening.</p> <p>Design</p> <p>Transversal study.</p> <p>Subjects</p> <p>One hundred and forty-five women over 40-years old participated in this study.</p> <p>Results</p> <p>In 39.3% of cases the BMI was above 30 kg/m²; 46.9% had hypertension, 14.5% had type 2 Diabetes Mellitus, 31.7% had dyslipidemia and 88.3% presented a waist-to-hip ratio ≥ 0.8. A linear correlation was found between serum levels of PAI-1 and triglycerides, between serum levels of PAI-1 and WHR and between serum levels of VCAM-1 and BMI.</p> <p>Conclusion</p> <p>We found a high prevalence of obesity and metabolic syndrome. PAI-1 and VCAM-1 levels were correlated with clinical indicators of obesity and overweight.</p>