Parathyroid Hormone-Related Peptide Elicits Peripheral TRPV1-dependent Mechanical Hypersensitivity

Parathyroid Hormone-Related Peptide Elicits Peripheral TRPV1-dependent Mechanical Hypersensitivity

Bone metastasis in breast, prostate and lung cancers often leads to chronic pain, which is poorly managed by existing analgesics. The neurobiological mechanisms that underlie chronic pain associated with bone-metastasized cancers are not well understood, but sensitization of peripheral nociceptors b...

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Bibliographic Details
Main Authors: Andrew J. Shepherd, Aaron D. Mickle, Suraj Kadunganattil, Hongzhen Hu, Durga P. Mohapatra
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
PTHrP
TRPV1
TRPA1
TRPV4
pain
mechanical pain
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00038/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00038/full

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