Selective G-Quadruplex DNA Recognition by a New Class of Designed Cyanines

Selective G-Quadruplex DNA Recognition by a New Class of Designed Cyanines

A variety of cyanines provide versatile and sensitive agents acting as DNA stains and sensors and have been structurally modified to bind in the DNA minor groove in a sequence dependent manner. Similarly, we are developing a new set of cyanines that have been designed to achieve highly selective bin...

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Bibliographic Details
Main Authors: Markus W. Germann, W. David Wilson, Maged M. Henary, Hang T. Huynh, Ekaterina M. Stroeva, Tyler L. Dost, Rupesh Nanjunda, Leah Mickelson, Eric A. Owens
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Molecules
Subjects:
G-quadruplex
cyanines
c-myc
telomere
end-stacking
halogenation
nuclear magnetic resonance
surface plasmon resonance
thermal melting
Online Access:http://www.mdpi.com/1420-3049/18/11/13588

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