| Summary: | Aim:
Resveratrol, catechin and epicatechin are known for their preventive effects of
skeletal muscle atrophy, anti-fatique effects and enhancement of exercise
capacity. In this study, we investigate the effects these antioxidants on
muscle contraction by using rat phrenic nerve hemi-diaphragm preparations. Methods:
Twitch responses are investigated by giving direct and indirect and tetanic
stimulation to rat phrenic nerve hemi-diaphragm preparations. Results:
Resveratrol and catechin facilitated twitch responses to the indirect stimulus
in short duration and suppressed in long duration. The decrease in the responses to the direct stimulation by applying epicatechin
(p=0.010) was significantly higher than the responses by giving indirect
stimulation. Epicatechin significantly suppressed tetanic responses (p=0.005), but not resveratrol and catechin.
Conclusion: The results
of the study show that these antioxidants have presynaptic and postsynaptic
effects on neuromuscular junction. Resveratrol effective on muscle contraction
via direct stimulus, catechin and epicatechin effects muscle contraction by
direct and indirect stimulus.
|
|---|
