Proteomics Complementation of the Rat Uterotrophic Assay for Estrogenic Endocrine Disruptors: A Roadmap of Advancing High Resolution Mass Spectrometry-Based Shotgun Survey to Targeted Biomarker Quantifications

Proteomics Complementation of the Rat Uterotrophic Assay for Estrogenic Endocrine Disruptors: A Roadmap of Advancing High Resolution Mass Spectrometry-Based Shotgun Survey to Targeted Biomarker Quantifications

The widely used rat uterotrophic assay to assess known and potential estrogenic compounds only considers uterine weight gain as endpoint measurement. To complement this method with an advanced technology that reveals molecular targets, we analyzed changes in protein expression using label-free quant...

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Bibliographic Details
Main Authors: Laszlo Prokai, Fatima Rahlouni, Khadiza Zaman, Vien Nguyen, Katalin Prokai-Tatrai
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
endocrine disruption
rat uterus
estrogen-regulated proteins
17β-estradiol
liquid chromatography–mass spectrometry
label-free proteomics
Online Access:https://www.mdpi.com/1422-0067/22/4/1686

Internet

https://www.mdpi.com/1422-0067/22/4/1686

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