Extrapolation of Drug Clearance in Children ≤ 2 Years of Age from Empirical Models Using Data from Children (> 2 Years) and Adults
Abstract Background The application of modeling and simulation approaches in clinical pharmacology studies has gained momentum over the last 20 years. Objectives The objective of this study was to develop six empirical models from clearance data obtained from children aged > 2 years and adults to...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2019-12-01
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| Series: | Drugs in R&D |
| Online Access: | https://doi.org/10.1007/s40268-019-00291-2 |