SHOX2 Overexpression Favors Differentiation of Embryonic Stem Cells into Cardiac Pacemaker Cells, Improving Biological Pacing Ability

SHOX2 Overexpression Favors Differentiation of Embryonic Stem Cells into Cardiac Pacemaker Cells, Improving Biological Pacing Ability

Summary: When pluripotency factors are removed, embryonic stem cells (ESCs) undergo spontaneous differentiation, which, among other lineages, also gives rise to cardiac sublineages, including chamber cardiomyocytes and pacemaker cells. Such heterogeneity complicates the use of ESC-derived heart cell...

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Bibliographic Details
Main Authors:	Vittoria Ionta, Wenbin Liang, Elizabeth H. Kim, Reza Rafie, Alessandro Giacomello, Eduardo Marbán, Hee Cheol Cho
Format:	Article
Language:	English
Published:	Elsevier 2015-01-01
Series:	Stem Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671114003543

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