Regulation of Hedgehog signaling Offers A Novel Perspective for Bone Homeostasis Disorder Treatment

Regulation of Hedgehog signaling Offers A Novel Perspective for Bone Homeostasis Disorder Treatment

The hedgehog (HH) signaling pathway is central to the regulation of bone development and homeostasis. HH signaling is not only involved in osteoblast differentiation from bone marrow mesenchymal stem cells (BM-MSCs), but also acts upstream within osteoblasts via the OPG/RANK/RANKL axis to control th...

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Bibliographic Details
Main Authors: Wen-Ting Lv, Dong-Hua Du, Rui-Juan Gao, Chun-Wei Yu, Yan Jia, Zhi-Feng Jia, Chun-Jie Wang
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
hedgehog
RANKL
osteoblast
PTHrP
CREB
NFAT
Online Access:https://www.mdpi.com/1422-0067/20/16/3981

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