Concomitant Intraocular Retinoblastoma and Choroidal Hemangioma in a 1-Year-Old Boy

• Main Authors: Yacoub A. YOUSEF, Maysa AL-HUSSAİNİ, Fareed H. BARAKAT, Alaa SALEH, Mona MOHAMMAD, Rasha DEEBAJAH
• Format: Article
• Language: English
• Published: Federation of Turkish Pathology Societies 2019-09-01
• Series: Türk Patoloji Dergisi
• Subjects: Choroidal neoplasm; Hemangioma; Leukocoria; Retinoblastoma
• Online Access: http://www.turkjpath.org/pdf.php3?id=1848

We report a case of concomitant choroidal hemangioma in an eye that harbored intraocular retinoblastoma (RB) in a 1-year-old child. A 12-month-old boy presented with right white pupil (Leukocoria). The initial clinical diagnosis was unilateral intraocular RB Group C. The eye was treated initially by systemic chemotherapy combined with focal consolidation therapy followed by I-125 plaque radiotherapy. Massive sub-retinal recurrence was seen 4 months later, and Magnetic Resonance Imaging (MRI) showed extra-scleral invasion of the tumor, and therefore enucleation was performed. Microscopic examination revealed a differentiated retinoblastoma associated at the site of the base of the tumor with choroidal hemangioma with trans-scleral invasion. Orbit MRI was repeated 3 months after the surgery, and there was no orbital tumor recurrence. We are reporting a rare case of pathologically concomitant choroidal hemangioma with trans-scleral invasion in an eye that harbored active recurrent intraocular RB. This trans-scleral extension of hemangioma was misinterpreted by MRI as extraocular retinoblastoma and resulted in enucleation.