The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage

The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage

To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and ultrastructural age-related changes of cardiac muscles fibers in wild-type and NLRP3-knockout mice, as well as studying the beneficial effect of melatonin therapy. The results clarified the beginning o...

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Bibliographic Details
Main Authors: Ramy K. A. Sayed, Marisol Fernández-Ortiz, Ibtissem Rahim, José Fernández-Martínez, Paula Aranda-Martínez, Iryna Rusanova, Laura Martínez-Ruiz, Reem M. Alsaadawy, Germaine Escames, Darío Acuña-Castroviejo
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
cardiomyocytes
NLRP3 inflammasome
mitochondria
CSA
ultrastructure
sarcopenia
Online Access:https://www.mdpi.com/2076-3921/10/8/1269

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