Klotho and PPAR Gamma Activation Mediate the Renoprotective Effect of Losartan in the 5/6 Nephrectomy Model

Klotho and PPAR Gamma Activation Mediate the Renoprotective Effect of Losartan in the 5/6 Nephrectomy Model

Renin angiotensin system (RAS) blockade reduces the progression of chronic kidney disease (CKD) independently of its antihypertensive effect. Ang II-induced fibrosis can be mediated by molecules such as klotho, peroxisome proliferator-activate receptor γ (PPAR-γ), and the Wnt/β-catenin pathway; howe...

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Bibliographic Details
Main Authors: Edgar Maquigussa, Josne C. Paterno, Gabriel H. de Oliveira Pokorny, Mariana da Silva Perez, Vanessa A. Varela, Antônio da Silva Novaes, Nestor Schor, Mirian A. Boim
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
klotho
angiotensin II
PPAR-γ
chronic kidney disease
hypertension
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01033/full

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