The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion

The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion

The role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus...

Full description

Bibliographic Details
Main Authors: Runqiu Jiang, Junwei Tang, Yun Chen, Lei Deng, Jie Ji, Yu Xie, Ke Wang, Wei Jia, Wen-Ming Chu, Beicheng Sun
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15129
id doaj-68f1a8b6ea584d59a60191c25afd516c
record_format Article
spelling doaj-68f1a8b6ea584d59a60191c25afd516c2021-05-11T07:17:11ZengNature Publishing GroupNature Communications2041-17232017-05-018111510.1038/ncomms15129The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasionRunqiu Jiang0Junwei Tang1Yun Chen2Lei Deng3Jie Ji4Yu Xie5Ke Wang6Wei Jia7Wen-Ming Chu8Beicheng Sun9Liver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical UniversityLiver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical UniversityDepartment of Microbiology and Immunology, Nanjing Medical UniversityLiver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical UniversityLiver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical UniversityLiver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical UniversityLiver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical UniversityMetabolomics Shared Resource, University of Hawaii Cancer CenterCancer Biology Program, University of Hawaii Cancer CenterLiver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical UniversityThe role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus promoting tumour growth via immune suppression.https://doi.org/10.1038/ncomms15129
collection DOAJ
language English
format Article
sources DOAJ
author Runqiu Jiang
Junwei Tang
Yun Chen
Lei Deng
Jie Ji
Yu Xie
Ke Wang
Wei Jia
Wen-Ming Chu
Beicheng Sun
spellingShingle Runqiu Jiang
Junwei Tang
Yun Chen
Lei Deng
Jie Ji
Yu Xie
Ke Wang
Wei Jia
Wen-Ming Chu
Beicheng Sun
The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
Nature Communications
author_facet Runqiu Jiang
Junwei Tang
Yun Chen
Lei Deng
Jie Ji
Yu Xie
Ke Wang
Wei Jia
Wen-Ming Chu
Beicheng Sun
author_sort Runqiu Jiang
title The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
title_short The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
title_full The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
title_fullStr The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
title_full_unstemmed The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
title_sort long noncoding rna lnc-egfr stimulates t-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description The role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus promoting tumour growth via immune suppression.
url https://doi.org/10.1038/ncomms15129
work_keys_str_mv AT runqiujiang thelongnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT junweitang thelongnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT yunchen thelongnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT leideng thelongnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT jieji thelongnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT yuxie thelongnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT kewang thelongnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT weijia thelongnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT wenmingchu thelongnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT beichengsun thelongnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT runqiujiang longnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT junweitang longnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT yunchen longnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT leideng longnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT jieji longnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT yuxie longnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT kewang longnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT weijia longnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT wenmingchu longnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
AT beichengsun longnoncodingrnalncegfrstimulatestregulatorycellsdifferentiationthuspromotinghepatocellularcarcinomaimmuneevasion
_version_ 1721452470710829056

Similar Items