Structural Basis of DNMT1 and DNMT3A-Mediated DNA Methylation

Structural Basis of DNMT1 and DNMT3A-Mediated DNA Methylation

DNA methylation, one of the major epigenetic mechanisms, plays critical roles in regulating gene expression, genomic stability and cell lineage commitment. The establishment and maintenance of DNA methylation in mammals is achieved by two groups of DNA methyltransferases (DNMTs): DNMT3A and DNMT3B,...

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Bibliographic Details
Main Authors: Wendan Ren, Linfeng Gao, Jikui Song
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Genes
Subjects:
DNMT1
DNMT3A
DNA methyltransferase
maintenance DNA methylation
de novo DNA methylation
allosteric regulation
autoinhibition
Online Access:https://www.mdpi.com/2073-4425/9/12/620

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