A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training

We have designed an assay that measures approach and avoidance behaviors in head-fixed mice at millisecond timescale, is compatible with standard electrophysiological and optical methods for measuring neuronal activity, and requires no training. The Virtual Burrow Assay simulates a scenario in which...

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Main Authors:	Andrew JP Fink, Richard Axel, Carl E Schoonover
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-04-01
Series:	eLife
Subjects:	virtual burrow assay habituation fear conditioning sensory discrimination exploration head-fixed behavior
Online Access:	https://elifesciences.org/articles/45658

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spelling	doaj-68e784c9c61941afbaff0ec74ec48bf22021-05-05T17:32:54ZengeLife Sciences Publications LtdeLife2050-084X2019-04-01810.7554/eLife.45658A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without trainingAndrew JP Fink0https://orcid.org/0000-0003-4191-3298Richard Axel1https://orcid.org/0000-0002-3141-4076Carl E Schoonover2https://orcid.org/0000-0002-6397-1010Department of Neuroscience, Howard Hughes Medical Institute, Columbia University, New York, United StatesDepartment of Neuroscience, Howard Hughes Medical Institute, Columbia University, New York, United StatesDepartment of Neuroscience, Howard Hughes Medical Institute, Columbia University, New York, United StatesWe have designed an assay that measures approach and avoidance behaviors in head-fixed mice at millisecond timescale, is compatible with standard electrophysiological and optical methods for measuring neuronal activity, and requires no training. The Virtual Burrow Assay simulates a scenario in which a mouse, poised at the threshold of its burrow, evaluates whether to exit the enclosure or to retreat inside. The assay provides a sensitive readout of habituation, discrimination and exploration, as well as avoidance of both conditioned and innately aversive cues.https://elifesciences.org/articles/45658virtual burrow assayhabituationfear conditioningsensory discriminationexplorationhead-fixed behavior
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Andrew JP Fink Richard Axel Carl E Schoonover
spellingShingle	Andrew JP Fink Richard Axel Carl E Schoonover A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training eLife virtual burrow assay habituation fear conditioning sensory discrimination exploration head-fixed behavior
author_facet	Andrew JP Fink Richard Axel Carl E Schoonover
author_sort	Andrew JP Fink
title	A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training
title_short	A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training
title_full	A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training
title_fullStr	A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training
title_full_unstemmed	A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training
title_sort	virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training
publisher	eLife Sciences Publications Ltd
series	eLife
issn	2050-084X
publishDate	2019-04-01
description	We have designed an assay that measures approach and avoidance behaviors in head-fixed mice at millisecond timescale, is compatible with standard electrophysiological and optical methods for measuring neuronal activity, and requires no training. The Virtual Burrow Assay simulates a scenario in which a mouse, poised at the threshold of its burrow, evaluates whether to exit the enclosure or to retreat inside. The assay provides a sensitive readout of habituation, discrimination and exploration, as well as avoidance of both conditioned and innately aversive cues.
topic	virtual burrow assay habituation fear conditioning sensory discrimination exploration head-fixed behavior
url	https://elifesciences.org/articles/45658
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A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training

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