Mutations of FLT3 receptor affect its surface glycosylation, intracellular localization, and downstream signaling
This review describes the effects of FLT3 mutations that alter its intracellular localization and modify its glycosylation, leading to differences in downstream signaling pathways. The most common type of FLT3 mutation, internal tandem duplication (FLT3-ITD), leads to localization in the endoplasmic...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048919300500 |