The transcription factor C/EBP-β mediates constitutive and LPS-inducible transcription of murine SerpinB2.

The transcription factor C/EBP-β mediates constitutive and LPS-inducible transcription of murine SerpinB2.

SerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, c...

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Bibliographic Details
Main Authors: Ekemini A Udofa, Brett W Stringer, Padmaja Gade, Donna Mahony, Marguerite S Buzza, Dhananjaya V Kalvakolanu, Toni M Antalis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3589482?pdf=render

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