The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression

Summary: The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal levels. To delineate essential and non-essential Mr...

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Bibliographic Details
Main Authors: Jun Hyun Kim, Malgorzata Grosbart, Roopesh Anand, Claire Wyman, Petr Cejka, John H.J. Petrini
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317259

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