Assessment of Tumor Mutational Burden in Pediatric Tumors by Real-Life Whole-Exome Sequencing and In Silico Simulation of Targeted Gene Panels: How the Choice of Method Could Affect the Clinical Decision?

Assessment of Tumor Mutational Burden in Pediatric Tumors by Real-Life Whole-Exome Sequencing and In Silico Simulation of Targeted Gene Panels: How the Choice of Method Could Affect the Clinical Decision?

Background: Tumor mutational burden (TMB) is an emerging genomic biomarker in cancer that has been associated with improved response to immune checkpoint inhibitors (ICIs) in adult cancers. It was described that variability in TMB assessment is introduced by different laboratory techniques and vario...

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Bibliographic Details
Main Authors: Hana Noskova, Michal Kyr, Karol Pal, Tomas Merta, Peter Mudry, Kristyna Polaskova, Tina Catela Ivkovic, Sona Adamcova, Tekla Hornakova, Marta Jezova, Leos Kren, Jaroslav Sterba, Ondrej Slaby
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
pediatric tumors
tumor mutational burden
tmb
whole-exome sequencing
gene panel sequencing
immune checkpoint inhibitors
Online Access:https://www.mdpi.com/2072-6694/12/1/230

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https://www.mdpi.com/2072-6694/12/1/230

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