Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.

Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.

To determine the role of innate immune responses in controlling influenza A virus replication, rhesus macaques (RM) were administered pegylated IFN-alpha prior to virus challenge. Systemic and mucosal pegylated IFN-alpha administration induced expression of the interferon-stimulated genes (ISG) MxA...

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Bibliographic Details
Main Authors: Shannon R Matzinger, Timothy D Carroll, Linda Fritts, Michael B McChesney, Christopher J Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3248419?pdf=render

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