Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.

To determine the role of innate immune responses in controlling influenza A virus replication, rhesus macaques (RM) were administered pegylated IFN-alpha prior to virus challenge. Systemic and mucosal pegylated IFN-alpha administration induced expression of the interferon-stimulated genes (ISG) MxA...

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Main Authors: Shannon R Matzinger, Timothy D Carroll, Linda Fritts, Michael B McChesney, Christopher J Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3248419?pdf=render
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spelling doaj-68ce9323c55c4d21904d12b58de6a8ec2020-11-25T01:53:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01612e2925510.1371/journal.pone.0029255Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.Shannon R MatzingerTimothy D CarrollLinda FrittsMichael B McChesneyChristopher J MillerTo determine the role of innate immune responses in controlling influenza A virus replication, rhesus macaques (RM) were administered pegylated IFN-alpha prior to virus challenge. Systemic and mucosal pegylated IFN-alpha administration induced expression of the interferon-stimulated genes (ISG) MxA and OAS in the airways. RM treated with IFN-alpha 24 hours prior to influenza virus challenge had significantly lower peak vRNA levels in the trachea compared to untreated animals. In addition to blunting viral replication, IFN-alpha treatment minimized the weight loss and spike in body temperature after influenza infection of RM. These results confirm the importance of IFN-alpha induced innate immune responses in the rapid control of influenza A virus replication in primates.http://europepmc.org/articles/PMC3248419?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Shannon R Matzinger
Timothy D Carroll
Linda Fritts
Michael B McChesney
Christopher J Miller
spellingShingle Shannon R Matzinger
Timothy D Carroll
Linda Fritts
Michael B McChesney
Christopher J Miller
Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.
PLoS ONE
author_facet Shannon R Matzinger
Timothy D Carroll
Linda Fritts
Michael B McChesney
Christopher J Miller
author_sort Shannon R Matzinger
title Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.
title_short Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.
title_full Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.
title_fullStr Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.
title_full_unstemmed Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.
title_sort exogenous ifn-alpha administration reduces influenza a virus replication in the lower respiratory tract of rhesus macaques.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2011-01-01
description To determine the role of innate immune responses in controlling influenza A virus replication, rhesus macaques (RM) were administered pegylated IFN-alpha prior to virus challenge. Systemic and mucosal pegylated IFN-alpha administration induced expression of the interferon-stimulated genes (ISG) MxA and OAS in the airways. RM treated with IFN-alpha 24 hours prior to influenza virus challenge had significantly lower peak vRNA levels in the trachea compared to untreated animals. In addition to blunting viral replication, IFN-alpha treatment minimized the weight loss and spike in body temperature after influenza infection of RM. These results confirm the importance of IFN-alpha induced innate immune responses in the rapid control of influenza A virus replication in primates.
url http://europepmc.org/articles/PMC3248419?pdf=render
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