Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.
To determine the role of innate immune responses in controlling influenza A virus replication, rhesus macaques (RM) were administered pegylated IFN-alpha prior to virus challenge. Systemic and mucosal pegylated IFN-alpha administration induced expression of the interferon-stimulated genes (ISG) MxA...
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2011-01-01
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doaj-68ce9323c55c4d21904d12b58de6a8ec2020-11-25T01:53:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01612e2925510.1371/journal.pone.0029255Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.Shannon R MatzingerTimothy D CarrollLinda FrittsMichael B McChesneyChristopher J MillerTo determine the role of innate immune responses in controlling influenza A virus replication, rhesus macaques (RM) were administered pegylated IFN-alpha prior to virus challenge. Systemic and mucosal pegylated IFN-alpha administration induced expression of the interferon-stimulated genes (ISG) MxA and OAS in the airways. RM treated with IFN-alpha 24 hours prior to influenza virus challenge had significantly lower peak vRNA levels in the trachea compared to untreated animals. In addition to blunting viral replication, IFN-alpha treatment minimized the weight loss and spike in body temperature after influenza infection of RM. These results confirm the importance of IFN-alpha induced innate immune responses in the rapid control of influenza A virus replication in primates.http://europepmc.org/articles/PMC3248419?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shannon R Matzinger Timothy D Carroll Linda Fritts Michael B McChesney Christopher J Miller |
spellingShingle |
Shannon R Matzinger Timothy D Carroll Linda Fritts Michael B McChesney Christopher J Miller Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques. PLoS ONE |
author_facet |
Shannon R Matzinger Timothy D Carroll Linda Fritts Michael B McChesney Christopher J Miller |
author_sort |
Shannon R Matzinger |
title |
Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques. |
title_short |
Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques. |
title_full |
Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques. |
title_fullStr |
Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques. |
title_full_unstemmed |
Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques. |
title_sort |
exogenous ifn-alpha administration reduces influenza a virus replication in the lower respiratory tract of rhesus macaques. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2011-01-01 |
description |
To determine the role of innate immune responses in controlling influenza A virus replication, rhesus macaques (RM) were administered pegylated IFN-alpha prior to virus challenge. Systemic and mucosal pegylated IFN-alpha administration induced expression of the interferon-stimulated genes (ISG) MxA and OAS in the airways. RM treated with IFN-alpha 24 hours prior to influenza virus challenge had significantly lower peak vRNA levels in the trachea compared to untreated animals. In addition to blunting viral replication, IFN-alpha treatment minimized the weight loss and spike in body temperature after influenza infection of RM. These results confirm the importance of IFN-alpha induced innate immune responses in the rapid control of influenza A virus replication in primates. |
url |
http://europepmc.org/articles/PMC3248419?pdf=render |
work_keys_str_mv |
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