REV7 is required for processing AID initiated DNA lesions in activated B cells

REV7 is required for processing AID initiated DNA lesions in activated B cells

REV7 has emerged as a critical regulator of DNA double-strand breaks repair. Here, the authors show that REV7 is crucial for both antibody class switch recombination and somatic hypermutation in activated B cells, in addition to their survival upon AID-deamination.

Bibliographic Details
Main Authors: Dingpeng Yang, Ying Sun, Jingjing Chen, Ying Zhang, Shuangshuang Fan, Min Huang, Xia Xie, Yanni Cai, Yafang Shang, Tuantuan Gui, Liming Sun, Jiazhi Hu, Junchao Dong, Leng-Siew Yeap, Xiaoming Wang, Wei Xiao, Fei-Long Meng
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16632-8

Internet

https://doi.org/10.1038/s41467-020-16632-8

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