BCPA {<i>N</i>,<i>N</i>′-1,4-Butanediylbis[3-(2-chlorophenyl)acrylamide]} Inhibits Osteoclast Differentiation through Increased Retention of Peptidyl-Prolyl <i>cis-trans</i> Isomerase Never in Mitosis A-Interacting 1

BCPA {<i>N</i>,<i>N</i>′-1,4-Butanediylbis[3-(2-chlorophenyl)acrylamide]} Inhibits Osteoclast Differentiation through Increased Retention of Peptidyl-Prolyl <i>cis-trans</i> Isomerase Never in Mitosis A-Interacting 1

Osteoporosis is caused by an imbalance of osteoclast and osteoblast activities and it is characterized by enhanced osteoclast formation and function. Peptidyl-prolyl cis-trans isomerase never in mitosis A (NIMA)-interacting 1 (Pin1) is a key mediator of osteoclast cell-cell fusion via suppression of...

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Bibliographic Details
Main Authors: Eugene Cho, Jin-Kyung Lee, Jee-Young Lee, Zhihao Chen, Sun-Hee Ahn, Nam Doo Kim, Min-Suk Kook, Sang Hyun Min, Byung-Ju Park, Tae-Hoon Lee
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
Pin1
DC-STAMP
BCPA
osteoclast
osteoporosis
Online Access:https://www.mdpi.com/1422-0067/19/11/3436

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