The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in <i>Schizosaccharomyces pombe</i>

The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in <i>Schizosaccharomyces pombe</i>

In eukaryotes, heterochromatin plays a critical role in organismal development and cell fate acquisition, through regulating gene expression. The evolutionarily conserved lysine-specific demethylases, Lsd1 and Lsd2, remove mono- and dimethylation on histone H3, serving complex roles in gene expressi...

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Bibliographic Details
Main Authors: Bahjat F. Marayati, James F. Tucker, David A. De La Cerda, Tien-Chi Hou, Rong Chen, Tomoyasu Sugiyama, James B. Pease, Ke Zhang
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
Lsd1
Lsd2
heterochromatin
lysine demethylase
gene silencing
H3K9me2
Online Access:https://www.mdpi.com/2073-4409/9/4/955

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