KDT501, a derivative from hops, normalizes glucose metabolism and body weight in rodent models of diabetes.

AIMS/HYPOTHESIS: We developed KDT501, a novel substituted 1,3-cyclopentadione chemically derived from hop extracts, and evaluated it in various in vitro and in vivo models of diabetes and insulin sensitivity. METHODS: KDT501 was evaluated for anti-inflammatory effects in monocyte/macrophage cells; a...

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Bibliographic Details
Main Authors: Veera R Konda, Anuradha Desai, Gary Darland, Neile Grayson, Jeffrey S Bland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3907559?pdf=render