Cerebellar atrophy related to chronic exposure to toluene: case report

• Main Authors: Benito Pereira Damasceno, Eduardo Mello de Capitani
• Format: Article
• Language: English
• Published: Academia Brasileira de Neurologia (ABNEURO) 1994-03-01
• Series: Arquivos de Neuro-Psiquiatria
• Subjects: atrofia cerebelar; neurotoxicidade; solventes orgânicos; tolueno
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1994000100017&lng=en&tlng=en

A 31-year-old woman presented slowly progressing ataxia and neurasthenic symptoms after 14-year occupational exposure to low concentration toluene vapour. Examination disclosed only cerebellar signs. Cognitive functions were normal except moderate visuo-spatial and constructive deficit CT imaging showed severe pancerebellar atrophy without pathological signs in other brain structures. Two years after she was removed from workplace, CT imaging and ataxia showed no worsening, while visuo-constructive function improved. The authors warn against possible neurotoxic risk associated with this kind of exposure.