Vascular endothelial growth factor in diagnostics of metastases of a muscleinvasive bladder cancer

• Main Authors: V. M. Popkov, A. N. Ponukalin, N. B. Zakharova
• Format: Article
• Language: Russian
• Published: ABV-press 2016-06-01
• Series: Onkourologiâ
• Subjects: muscle-invasive bladder cancer; vascular endothelial growth factor; blood serum; plasma; diagnostic factor; prognostic factor
• Online Access: https://oncourology.abvpress.ru/oncur/article/view/575

Objective. The diagnostic value of vascular endothelial growth factor (VEGF) in muscle-invasive bladder cancer (MIBC) was estimated.Materials and methods. The level of VEGF was determined by ELISA in blood serum, plasma of patients with cancer invasion within the bladder or with extra-bladder invasion before surgical treatment and of patients with recurrences and metastases or without them 12–18 months after surgical treatment.Results. Concentration of VEGF was shown to be one of criteria of activity in this disease. Thus, increasing of VEGF level correlated with the degree of the tumor invasion being one of criteria of its aggressive character and malignancy as well as its metastatic potential. At the same time, decreasing of concentration of this biomarker in patients with MIBC in the post-operative period was followed by limitation or absence of clinical manifestation of the tumor progression.Conclusions. Thus, detection of VEGF in blood serum, plasma can serve as the basis for development of new methods of early non-invasive diagnostics of MIBC, prognosis of its course and estimation of the efficiency of treatment.