Controlling pH in shake flasks using polymer-based controlled-release discs with pre-determined release kinetics

<p>Abstract</p> <p>Background</p> <p>There are significant differences in the culture conditions between small-scale screenings and large-scale fermentation processes. Production processes are usually conducted in fed-batch cultivation mode with active pH-monitoring and...

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Bibliographic Details
Main Authors: Klee Doris, Ikeda Hideo, Klinger Johannes, Dittrich Barbara, Scheidle Marco, Büchs Jochen
Format: Article
Language:English
Published: BMC 2011-03-01
Series:BMC Biotechnology
Online Access:http://www.biomedcentral.com/1472-6750/11/25