Tritiated bile acids: problems and recommendations

Tritiated bile acids: problems and recommendations

Kinetic studies of cholic and chenodeoxycholic acids were carried out in three patients by simultaneous intravenous administration of appropriate pairs of 3H- and 14C-labeled compounds. The results obtained indicated two sources of error: chemical impurity and loss of tritium by biological exchange....

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Bibliographic Details
Main Authors: D.K. Panveliwalla, D. Pertsemlidis, E.H. Ahrens, Jr.
Format: Article
Language:English
Published: Elsevier 1974-09-01
Series:Journal of Lipid Research
Subjects:
[2,4-3H]cholic acid
[random-3H]chenodeoxycholic acid
purity
tritium exchange
kinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520367754
Description
Summary:Kinetic studies of cholic and chenodeoxycholic acids were carried out in three patients by simultaneous intravenous administration of appropriate pairs of 3H- and 14C-labeled compounds. The results obtained indicated two sources of error: chemical impurity and loss of tritium by biological exchange. Precautions are listed for use of tritiated bile acids in studies of pool sizes and turnover rates.
ISSN:0022-2275

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