Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy
Solid tumors are known to recruit new blood vessels to support their growth. Therefore, unique molecules expressed on tumor endothelial cells can function as targets for the antiangiogenic therapy of cancer. Current efforts are focusing on developing therapeutic agents capable of specifically target...
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Series: | Journal of Oncology |
Online Access: | http://dx.doi.org/10.1155/2010/723798 |
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doaj-688cd42febdc416588c6e45ff622f7e62020-11-24T21:13:36ZengHindawi LimitedJournal of Oncology1687-84501687-84692010-01-01201010.1155/2010/723798723798Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer TherapyHan-Chung Wu0De-Kuan Chang1Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, TaiwanInstitute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, TaiwanSolid tumors are known to recruit new blood vessels to support their growth. Therefore, unique molecules expressed on tumor endothelial cells can function as targets for the antiangiogenic therapy of cancer. Current efforts are focusing on developing therapeutic agents capable of specifically targeting cancer cells and tumor-associated microenvironments including tumor blood vessels. These therapies hold the promise of high efficacy and low toxicity. One recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics is to encapsulate anticancer drugs into targeting liposomes that bind to the cell surface receptors expressed on tumor-associated endothelial cells. These anti-angiogenic drug delivery systems could be used to target both tumor blood vessels as well as the tumor cells, themselves. This article reviews the mechanisms and advantages of various present and potential methods using peptide-conjugated liposomes to specifically destroy tumor blood vessels in anticancer therapy.http://dx.doi.org/10.1155/2010/723798 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Han-Chung Wu De-Kuan Chang |
spellingShingle |
Han-Chung Wu De-Kuan Chang Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy Journal of Oncology |
author_facet |
Han-Chung Wu De-Kuan Chang |
author_sort |
Han-Chung Wu |
title |
Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy |
title_short |
Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy |
title_full |
Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy |
title_fullStr |
Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy |
title_full_unstemmed |
Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy |
title_sort |
peptide-mediated liposomal drug delivery system targeting tumor blood vessels in anticancer therapy |
publisher |
Hindawi Limited |
series |
Journal of Oncology |
issn |
1687-8450 1687-8469 |
publishDate |
2010-01-01 |
description |
Solid tumors are known to recruit new blood vessels to support their growth. Therefore, unique molecules expressed on tumor endothelial cells can function as targets for the antiangiogenic therapy of cancer. Current efforts are focusing on developing therapeutic agents capable of specifically targeting cancer cells and tumor-associated microenvironments including tumor blood vessels. These therapies hold the promise of high efficacy and low toxicity. One recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics is to encapsulate anticancer drugs into targeting liposomes that bind to the cell surface receptors expressed on tumor-associated endothelial cells. These anti-angiogenic drug delivery systems could be used to target both tumor blood vessels as well as the tumor cells, themselves. This article reviews the mechanisms and advantages of various present and potential methods using peptide-conjugated liposomes to specifically destroy tumor blood vessels in anticancer therapy. |
url |
http://dx.doi.org/10.1155/2010/723798 |
work_keys_str_mv |
AT hanchungwu peptidemediatedliposomaldrugdeliverysystemtargetingtumorbloodvesselsinanticancertherapy AT dekuanchang peptidemediatedliposomaldrugdeliverysystemtargetingtumorbloodvesselsinanticancertherapy |
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1716748642744795136 |