Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy

Solid tumors are known to recruit new blood vessels to support their growth. Therefore, unique molecules expressed on tumor endothelial cells can function as targets for the antiangiogenic therapy of cancer. Current efforts are focusing on developing therapeutic agents capable of specifically target...

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Main Authors: Han-Chung Wu, De-Kuan Chang
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2010/723798
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spelling doaj-688cd42febdc416588c6e45ff622f7e62020-11-24T21:13:36ZengHindawi LimitedJournal of Oncology1687-84501687-84692010-01-01201010.1155/2010/723798723798Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer TherapyHan-Chung Wu0De-Kuan Chang1Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, TaiwanInstitute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, TaiwanSolid tumors are known to recruit new blood vessels to support their growth. Therefore, unique molecules expressed on tumor endothelial cells can function as targets for the antiangiogenic therapy of cancer. Current efforts are focusing on developing therapeutic agents capable of specifically targeting cancer cells and tumor-associated microenvironments including tumor blood vessels. These therapies hold the promise of high efficacy and low toxicity. One recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics is to encapsulate anticancer drugs into targeting liposomes that bind to the cell surface receptors expressed on tumor-associated endothelial cells. These anti-angiogenic drug delivery systems could be used to target both tumor blood vessels as well as the tumor cells, themselves. This article reviews the mechanisms and advantages of various present and potential methods using peptide-conjugated liposomes to specifically destroy tumor blood vessels in anticancer therapy.http://dx.doi.org/10.1155/2010/723798
collection DOAJ
language English
format Article
sources DOAJ
author Han-Chung Wu
De-Kuan Chang
spellingShingle Han-Chung Wu
De-Kuan Chang
Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy
Journal of Oncology
author_facet Han-Chung Wu
De-Kuan Chang
author_sort Han-Chung Wu
title Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy
title_short Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy
title_full Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy
title_fullStr Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy
title_full_unstemmed Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy
title_sort peptide-mediated liposomal drug delivery system targeting tumor blood vessels in anticancer therapy
publisher Hindawi Limited
series Journal of Oncology
issn 1687-8450
1687-8469
publishDate 2010-01-01
description Solid tumors are known to recruit new blood vessels to support their growth. Therefore, unique molecules expressed on tumor endothelial cells can function as targets for the antiangiogenic therapy of cancer. Current efforts are focusing on developing therapeutic agents capable of specifically targeting cancer cells and tumor-associated microenvironments including tumor blood vessels. These therapies hold the promise of high efficacy and low toxicity. One recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics is to encapsulate anticancer drugs into targeting liposomes that bind to the cell surface receptors expressed on tumor-associated endothelial cells. These anti-angiogenic drug delivery systems could be used to target both tumor blood vessels as well as the tumor cells, themselves. This article reviews the mechanisms and advantages of various present and potential methods using peptide-conjugated liposomes to specifically destroy tumor blood vessels in anticancer therapy.
url http://dx.doi.org/10.1155/2010/723798
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AT dekuanchang peptidemediatedliposomaldrugdeliverysystemtargetingtumorbloodvesselsinanticancertherapy
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