Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study

Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study

Abstract Background Little is known about the effects of chemotherapeutic drugs on DNA methylation status of leukocytes, which may be predictive of treatment benefits and toxicities. Based on a prospective national study, we characterize the changes in leukocyte DNA methylome from pre- to post-chemo...

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Main Authors: Song Yao, Qiang Hu, Sarah Kerns, Li Yan, Adedayo A. Onitilo, Jamal Misleh, Kelley Young, Lianlian Lei, Javier Bautista, Mostafa Mohamed, Supriya G. Mohile, Christine B. Ambrosone, Song Liu, Michelle C. Janelsins
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Chemotherapy
Breast cancer
Cognitive function
Online Access:http://link.springer.com/article/10.1186/s13148-019-0641-1

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