Structural mechanism of laminin recognition by integrin

Structural mechanism of laminin recognition by integrin

Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molecular detail.

Bibliographic Details
Main Authors: Takao Arimori, Naoyuki Miyazaki, Emiko Mihara, Mamoru Takizawa, Yukimasa Taniguchi, Carlos Cabañas, Kiyotoshi Sekiguchi, Junichi Takagi
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24184-8
Description
Summary:Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molecular detail.
ISSN:2041-1723

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