LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression

• Main Authors: Ting Huang, Yong-Jie Wang, Mi-Tao Huang, Yu Guo, Li-Chang Yang, Xiao-Jin Liu, Wu-Yuan Tan, Jian-Hong Long
• Format: Article
• Language: English
• Published: Nature Publishing Group 2021-04-01
• Series: Cell Death and Disease
• Online Access: https://doi.org/10.1038/s41419-021-03612-z

Abstract Recently studies found that APEX1 was abnormally expressed in melanoma, indicating that it might be involved in the development of melanoma. However, the underlying mechanism and the interaction between APEX1 and LINC00470 in melanoma are not clear. Therefore, we aimed to investigate the role of LINC00470 in the development of melanoma in this work. We discovered that LINC00470 was overexpressed in melanoma tissues and cells compared with the adjacent normal tissues and cells by qPCR. The overexpression of LINC00470 promoted the proliferation and migration of melanoma cells. The functional investigation demonstrated that LINC00470 activated the transcription factor, ZNF131, to regulate the APEX1 expression, which finally promoted cell proliferation and migration. In contrast, knockdown of LINC00470 could significantly inhibit the melanoma cell proliferation and migration, and suppress the growth of tumor in vivo. Overexpression of APEX1 could reverse the impact of the silence of LINC00470 in melanoma cells. In summary, our studies revealed that LINC00470 promoted melanoma proliferation and migration by enhancing the expression of APEX1, which indicated that LINC00470 might be a therapeutic target for the treatment of melanoma.