Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development

MLL-AF4+ infant B cell acute lymphoblastic leukemia is characterized by an early onset and dismal survival. It initiates before birth, and very little is known about the early stages of the disease’s development. Using a conditional Mll-AF4-expressing mouse model in which fusion expression is target...

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Bibliographic Details
Main Authors: Neil A. Barrett, Camille Malouf, Chrysa Kapeni, Wendi A. Bacon, George Giotopoulos, Sten Eirik W. Jacobsen, Brian J. Huntly, Katrin Ottersbach
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308002

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