TRAIL-Mediated Suppression of T Cell Receptor Signaling Inhibits T Cell Activation and Inflammation in Experimental Autoimmune Encephalomyelitis

TRAIL-Mediated Suppression of T Cell Receptor Signaling Inhibits T Cell Activation and Inflammation in Experimental Autoimmune Encephalomyelitis

ObjectiveTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces cell apoptosis by transducing apoptosis signals after interacting with its receptor (TRAIL-R). Although the actual biological role of TRAIL remains to be elucidated, recent accumulating evidence implies that TRAIL regul...

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Bibliographic Details
Main Authors: I-Tsu Chyuan, Hwei-Fang Tsai, Chien-Sheng Wu, Chi-Chang Sung, Ping-Ning Hsu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
TRAIL
T cell receptor signaling
T cell activation
experimental autoimmune encephalomyelitis
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00015/full

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