Tolerance of protein folding to a circular permutation in a PDZ domain.

Tolerance of protein folding to a circular permutation in a PDZ domain.

Circular permutation is a common molecular mechanism for evolution of proteins. However, such re-arrangement of secondary structure connectivity may interfere with the folding mechanism causing accumulation of folding intermediates, which in turn can lead to misfolding. We solved the crystal structu...

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Bibliographic Details
Main Authors: Greta Hultqvist, Avinash S Punekar, Angela Morrone, Celestine N Chi, Ake Engström, Maria Selmer, Stefano Gianni, Per Jemth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3503759?pdf=render

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